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| Biocidal Properties of Copper (II) Soap Complex Derived From Natural Edible Oil | ||||||||||
| Paper Id :
16750 Submission Date :
16/11/2022 Acceptance Date :
23/11/2022 Publication Date :
25/11/2022
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| Abstract | The primary purpose of this research to understand the characteristic nature and biocidal applications of copper soap complexes with nitrogen and sulphur donor ligands. The present research work reports fundamental chemical properties and new investigations of coordination compounds of some transition metal ions with an overview of medicinal applications. Transition metals appear in almost every facet of our day-to-day life, from industrial uses such as the manufacture of construction and building materials, tools, vehicles, up to cosmetics, paints and fertilizers. Their reactions are in general important in many technical processes such as catalysis, material synthesis, photochemistry, as well as, in biology and medicine. The present work deals with the study of synthesis and characterization of biological properties of copper (II) soap urea complex derived from sesame oil. | |||||||||
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| Keywords | Donor Ligands, Transition Metals, Characterization, Biocidal Properties, Sesame Oil. | |||||||||
| Introduction |
Metal complexes of the ligands containing sulphur and nitrogen as donor atoms are known to obtain bactericidal, antiviral and carcinostatic activities. Benzothiazoles are bicyclic ring system with various applications which have been the subject of great importance because of their biological activities. The aim of the present study to synthesis safer surfactants and to describe their degradation from environment. The present study focused on the antimicrobial activities of copper (II) soap complexes derived from edible oil such as sesame oil with ligand containing nitrogen, oxygen and sulphur atoms, which are crucial for their significant activity. In addition microbiological influence of the copper (II) soap complexes against staphylococcus aureus are investigated and reported. This review reveals that the pharmacologically interesting copper soap complexes could be a suitable strategy to develop novel therapeutic tools for the medical treatment. |
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| Aim of study | The aim of this research work reveals characterization and new investigations of biological applications of copper (II) sesame soap urea complex. | |||||||||
| Review of Literature | From the literature survey, it appears that copper (II) soap complexes with nitrogen and sulphur containing ligands have special significance in the field of medicinal chemistry due to their remarkable pharmacological potentialities [1-2]. Research has shown significant progress in industrial utilization of these copper soap complexes as antimicrobial activities against Staphylococus aureus. These results shows that nature of different nitrogen and sulphur containing ligands coordinated with metal ion play a significant role in the inhibition activity [3-6]. In recent times the coordination chemistry of nitrogen and sulphur containing ligands has reputed greater importance in view of the fact that several of these compounds have been found to be biologically active and have found use in medicine as well as in industry [7-8]. In microbiological influence of the copper (II) soap complexes against staphylococcus aureus are investigated and reported. This review reveals that the pharmacologically interesting copper soap complexes could be a suitable strategy to develop novel therapeutic tools for the medical treatment [9-11]. |
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| Main Text | ||||||||||
| Methodology | Copper (II) soaps were prepared by direct metathesis process. In this process, the oils were refluxed with 2N KOH solution and ethyl alcohol for about 3 hours. 1N HCl was used for neutralization of excess KOH. After initial drying in air oven at 100-105 °C, these copper soaps were further purified by recrystallization with hot benzene several times. The metal was analyzed by standard procedure [12]. These copper soaps were of green in colour are obtained. Care was taken to avoid traces of water which were found to hydrolyze the soap. The copper (II) soap complexes were prepared by reacting ethanolic solution of ligand (Urea) with copper (II) soap in 1:1 molar ratio. In 25-30 ml of ethyl alcohol, 0.001 moles of ligand molecule was dissolved and in 10-15 ml of benzene, 0.001 moles of copper (II) soap derived from sesame oil was dissolved and then ethanolic solution of ligand was added in it. After this reaction mixture was refluxed for about two hours with constant stirring. |
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| Result and Discussion | IR Spectral Analysis In order to study the structure of copper (II) sesame soap complex, the Infra-red spectra of compound was obtained on a spectrophotometer from Dept. of chemistry, S.P.C. Govt. College Ajmer in the range from 4000-400 cm-1 (Fig 1).
Figure 1 IR spectra of copper
(II) sesame-urea complex Antimicrobial Studies All the Copper (II) sesame soap complexes were
screened for their antibacterial activity against Staphylococcus aureus.
These complexes were tested at different concentrations after 24 and 48 hours
incubation times and zone of inhibition have been measured in mm. Table 1
shows the biological activities of copper (II) soap complexes determined by
screening against bacteria at 5×104 ppm and 2.5×104 ppm.
The copper (II) sesame soap complexes with ligand like urea were screened for
their antibacterial activity against Staphylococcus aureus. These
compounds were tested at different concentrations and zone of inhibition have
been measured in mm [13-14]. Table 1. Zone of inhibition of copper (II) sesame soap
complexes against Staphylococcus aureus.
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| Findings | The antibacterial activity increases with the increase in the concentration of the solution. | |||||||||
| Conclusion | In conclusion, the present work shows relevant biological properties of newly bio-based surfactants from natural edible oil such as sesame, in terms of antimicrobial activities against Staphylococcus aureus. Biological studies demonstrate that the nitrogen, oxygen, and sulphur containing ligands are responsible to enhance the efficacy of synthesized complexes. | |||||||||
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