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The application of acid catalysts is very important in the pharmaceutical industry application chemical and refinery industries, and those technologies employing highly corrosive, hazardous and polluting conventional liquid acids and Lewis acids such as Phosphoric acid, PPA, nitric acid, H2SO4, HCl, HF, HClO4, H3PO4, AlCl3, BF3, ZnCl2 and SbF5 to overcome the above problem solid green catalyst introduced in the synthesis of pharmaceutical, chemicals and refinery industry. Heterogeneous catalyst are characterized by various advantages which include easy handling, recyclability in the process engineering, catalyst regeneration and cost effective. This phenomenon decreasing reactor and plant corrosion problems and environmentally safe disposal [1-15]. Over the past few decades, zirconia (ZrO2) based solid acids have received much attention, among other solid acids, due to their superior catalytic activity for hydrocarbon conversions at mild conditions [2,8,14-18]. 5-chloro-2,3-dihydro-1H-inden-1-one which is an intermediate raw material for medicines, such as antitussive and expectorant, and used in many purpose to synthesize these molecules using green chemistry tool. 5-chloro-2,3-dihydro-1H-inden-1-one involved in the Irie′s synthesis of substituted pyridines [19] 5-Chloro-1-indanone may being as starting reagent for the preparation of 5-chloro-2-methoxycarbonyl-1-indanone [20] .Having important biomedical compounds such as anticonvulsants, anticholinergics and diary sulfonylureas, having potential activity against solid tumors.

Procedure for the preparation of the catalyst: The catalyst prepared using a mixture of aqueous solutions of yttrium nitrate and zirconyl nitrate (molar ratio 16:84) with aqueous ammonia (28%) under vigorous stirring until a pH value of 8-8.5 was achieved and a precipitate was formed. Downloaded by: National University of Singapore. Copyrighted material. LETTER Yttria-Zirconia Based Lewis Acid 209 , Synlett 2001, No. 2, 206–209 ISSN 0936-5214 © Thieme Stuttgart · New York. Precipitate was washed with deionized water, dried at 110°C, treated with 2N sulfuric acid, dried again at 120°C for 24 h. The subsequent programmed calcination at 500°C for 3 h at a heating rate of 2°C min- 1 resulted in a highly acidic material. (a) 5-chloro-2,3-dihydro-1H-inden-1-one In a typical experimental procedure, compound 1 (20 mmol; 1.0 equiv) was added in toluene 20 ml of dry toluene and followed by addition of catalyst (10 % by weight), and the mixture was heated refluxed for 100-110 oC the indicated length of time (Table 1–2). The progress of the reaction monitored by monitored by TLC. After completion of reaction, the catalyst was filtered and kept aside for recycling purpose. Filtrate mother liquor diluted with water (30 ml). The organic layer was separated, washed with 10 % aq. NaHCO3, brine followed by water and dried over Na2SO4. The solvent was removed and the crude product was chromatographed on a silica gel column to afford the pure product using hexane ethyl acetate (9: 1). After the reaction, the catalyst is recovered with retention of its catalytic activity. It can be further reactivated for reuse by heating it at 500 °C in the presence of air. The substrates examined in our studies and the results obtained are summarized in Table 1 and table 2. Table1: Experimental detail of 5-chloro-2,3-dihydro-1H-inden-1-one from 3-chlorophenyl propionic acid using green Yttria zirconia based heterogeneous catalysis are summarized in below table.

Product were characterized by 1H NMR CDCl3 2.47 (3H, S), 6.38-6.40 (2H, dd), 7.22-7.26(2H, dd), 9.48 OH (bs) and

IR in cm-1: ; C=O peaks 1715 cm-1, OH peak 2400 cm-1, Mass spectrum MS+1, (167) and its correspond to the authentic sample 28.

The Experimental details are summarized in Table-1  & Table-2
Table1: Experimental detail of 5-chloro-2,3-dihydro-1H-inden-1-one from 3-chlorophenyl propionic acid  using green Yttria zirconia based heterogeneous catalysis are summarized in below table.

Isolated yield:*b Column chromatography *** NA: Not applicable 
Table 2. Summary of experimental detail with respect to variation of catalyst mol % / time/ temperature verses % Yield. 

Isolated yield:*b Column chromatography *** NA: Not applicable 

Sample analyzed  and matched with Authentic samples using NMR , IR 

The literature showed highly corrosive, hazardous and polluting conventional liquid acids and Lewis acids such as Phosphoric acid, PPA, nitric acid, H2SO4, HCl, HF, HClO4, H3PO4, AlCl3, BF3, ZnCl2 to overcome the above process. We have plan to synthesize using Green catalyst. Which gives high selectivity, easy work procedure and high yield > 98 % in very short span of time.

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